Engineering advanced neural tissue constructs to mitigate acute cerebral inflammation after brain transplantation in rats.

ABSTRACT: Stroke, traumatic brain injuries, and other similar conditions often lead to significant loss of functional brain tissue and associated disruption of neuronal signaling. A common strategy for replacing lost neurons is the injection of dissociated neural stem cells or differentiated neurons. However, this method is unlikely to be suitable for replacing large brain cavities, and the resulting distribution of neurons may lack the necessary architecture to support appropriate brain function. Engineered neural tissues may be a viable alternative. Cell death is a prominent concern in neuronal grafting studies, a problem that could be magnified with the transplantation of engineered neural tissues. Here, we examined the effect of one contributor to cell death, acute cerebral inflammation, on neur

SUBMITTER: Liaudanskaya V 

PROVIDER: S-EPMC6331257 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature