Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation.

ABSTRACT: The plasticity of developing tissues relies on the adjustment of cell survival and growth rate to environmental cues. This includes the effect of mechanical cues on cell survival. Accordingly, compaction of an epithelium can lead to cell extrusion and cell death. This process was proposed to contribute to tissue homeostasis but also to facilitate the expansion of pretumoral cells through the compaction and elimination of the neighboring healthy cells. However, we know very little about the pathways that can trigger apoptosis upon tissue deformation, and the contribution of compaction-driven death to clone expansion has never been assessed in vivo. Using the Drosophila pupal notum and a new live sensor of ERK, we show first that tissue compaction induces cell elimination through the downreg

SUBMITTER: Moreno E 

PROVIDER: S-EPMC6331351 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature