Loss of JAK1 Drives Innate Immune Deficiency.

ABSTRACT: The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway is critical in tuning immune responses and its dysregulation is tightly associated with cancer and immune disorders. Disruption of interleukin (IL)-15/STAT5 signaling pathway due to the loss of IL-15 receptor chains, JAK3 or STAT5 leads to immune deficiencies with natural killer (NK) cell abnormalities. JAK1, together with JAK3 transmits signals downstream of IL-15, but the exact contribution of JAK1 to NK cell biology remains to be elucidated. To study the consequences of JAK1 deficiency in NK cells, we generated mice with conditional deletion of JAK1 in NKp46⁺ cells (Jak1^fl/flNcr1Cre). We show here that deletion of NK cell-intrinsic JAK1 signi

SUBMITTER: Witalisz-Siepracka A 

PROVIDER: S-EPMC6331462 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature