Dimethyl fumarate treatment induces lipid metabolism alterations that are linked to immunological changes.

ABSTRACT:

Objective

Identify metabolic changes produced by dimethyl fumarate (DMF) treatment and link them to immunological effects.

Methods

We enrolled 18 MS patients and obtained blood prior to DMF and 6 months postinitiation. We also enrolled 18 healthy controls for comparison. We performed global metabolomics on plasma and used weighted correlation network analysis (WGCNA) to identify modules of correlated metabolites. We identified modules that changed with treatment, followed by targeted metabolomics to corroborate changes identified in global analyses. We correlated changes in metabolite modules and individual metabolites with changes in immunological parameters.

Results

We identified alterations in lipid metabolism after DMF treatment - increases in two modules (phospho

SUBMITTER: Bhargava P 

PROVIDER: S-EPMC6331509 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature