Memory effect of arsenic-induced cellular response and its influences on toxicity of titanium dioxide nanoparticle.

ABSTRACT: Toxicity of arsenic (As) has been widely characterized. However, few studies focus on whether cell responses induced by As at nontoxic concentration could be inherited and further change cell tolerance to another pollutant. In this study, human A549 and HeLa cells were exposed to As at nontoxic concentrations for 10 or 15 passages, then the cells were recovered in the cell medium without As. At 25th passage, residual As in both type of cells was completely removed through the recovery process. And no abnormity in cell viability was identified in both type of cells between control and As-treated groups. Above results indicated that As exposure-recovery treatment had limited influence on phenotype of the cells. However, gene expression profiles determined by high-throughput sequencing showed

SUBMITTER: Liu S 

PROVIDER: S-EPMC6331635 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature