Sex- and site-specific differences in colorectal cancer risk among people with type 2 diabetes.

ABSTRACT:

Purpose

The prevalence of colorectal cancer is higher among patients with type 2 diabetes mellitus (T2D) than among patients without diabetes. Furthermore, men are at higher risk for developing colorectal cancer than women in the general population and also subsite-specific risks differ per sex. The aim was to evaluate the impact of T2D on these associations.

Methods

A population-based matched cohort study was performed using data from the PHARMO Database Network. Patients with T2D were selected and matched (1:4) to diabetes free controls. Cox proportional hazards models were used to estimate hazard ratios (HRs) for CRC and its subsites. HRs were determined per sex and adjusted for age and socioeconomic status. The ratio of distal versus proximal colon cancer was calculated

SUBMITTER: Overbeek JA 

PROVIDER: S-EPMC6331739 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature