Bioconcentration studies with the freshwater amphipod Hyalella azteca: are the results predictive of bioconcentration in fish?

ABSTRACT: Bioconcentration factors (BCF) for regulatory purposes are usually determined by fish flow-through tests according to technical guidance document OECD 305. Fish bioconcentration studies are time consuming, expensive, and use many laboratory animals. The aim of this study was to investigate whether the freshwater amphipod Hyalella azteca can be used as an alternative test organism for bioconcentration studies. Fourteen substances of different hydrophobicity (log K_ow 2.4-7.6) were tested under flow-through conditions to determine steady state and kinetic bioconcentration factors (BCF_ss and BCF_k). The results were compared with fish BCF estimates for the same substances described in the literature to show the relationship between both values. Bioconcentration

SUBMITTER: Schlechtriem C 

PROVIDER: S-EPMC6331748 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature