Sensorimotor plasticity after spinal cord injury: a longitudinal and translational study.

ABSTRACT:

Objective

The objective was to track and compare the progression of neuroplastic changes in a large animal model and humans with spinal cord injury.

Methods

A total of 37 individuals with acute traumatic spinal cord injury were followed over time (1, 3, 6, and 12 months post-injury) with repeated neurophysiological assessments. Somatosensory and motor evoked potentials were recorded in the upper extremities above the level of injury. In a reverse-translational approach, similar neurophysiological techniques were examined in a porcine model of thoracic spinal cord injury. Twelve Yucatan mini-pigs underwent a contusive spinal cord injury at T10 and tracked with somatosensory and motor evoked potentials assessments in the fore- and hind limbs pre- (baseline, post-laminectomy) a

SUBMITTER: Jutzeler CR 

PROVIDER: S-EPMC6331953 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature