A New Ionone Glycoside and Three New Rhemaneolignans from the Roots of Rehmannia glutinosa.

ABSTRACT: A new ionone glycoside, frehmaglutoside I (1), and three new rhemaneolignans A-C (2-4) were isolated from the 95% EtOH extract of the roots of Rehmannia glutinosa. Their structures were determined by extensive spectroscopic (UV, IR, HR-ESI-MS, 1D and 2D NMR) analyses. In addition, these compounds were evaluated for their protective effects on cardiocytes impaired by doxorubicin in H9c2 cells. Among them, compounds 1-3 exhibited protective effects against DOX-induced cardiotoxicity.

SUBMITTER: Li M 

PROVIDER: S-EPMC6332001 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature