G-Quadruplex Forming Oligonucleotides as Anti-HIV Agents.

ABSTRACT: Though a variety of different non-canonical nucleic acids conformations have been recognized, G-quadruplex structures are probably the structural motifs most commonly found within known oligonucleotide-based aptamers. This could be ascribed to several factors, as their large conformational diversity, marked responsiveness of their folding/unfolding processes to external stimuli, high structural compactness and chemo-enzymatic and thermodynamic stability. A number of G-quadruplex-forming oligonucleotides having relevant in vitro anti-HIV activity have been discovered in the last two decades through either SELEX or rational design approaches. Improved aptamers have been obtained by chemical modifications of natural oligonucleotides, as terminal conjugations with large hydrophobic groups, rep

SUBMITTER: Musumeci D 

PROVIDER: S-EPMC6332060 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature