Quantitative 1H-NMR Method for the Determination of Tadalafil in Bulk Drugs and its Tablets.

ABSTRACT: A simple, rapid, accurate, and selective quantitative nuclear magnetic resonance method for the determination of tadalafil in bulk drugs and its tablets was established and evaluated. Spectra were obtained in dimethylsulfoxide-d6 using 2,4-dinitrotoluene as the internal standard. In this study, the method's linearity, range, limit of quantification, stability, precision, and accuracy were validated. The results were consistent with those obtained from high-performance liquid chromatography analysis. Thus, the proposed method is a useful and practical tool for the determination of tadalafil in bulk drugs and its tablets.

SUBMITTER: Yang Q 

PROVIDER: S-EPMC6332277 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature