Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin.

ABSTRACT: To benefit from the optimized dissolution properties of active pharmaceutical ingredients in their amorphous forms, co-amorphisation as a viable tool to stabilize these amorphous phases is of both academic and industrial interest. Reports dealing with the physical stability and recrystallization behavior of co-amorphous systems are however limited to qualitative evaluations based on the corresponding X-ray powder diffractograms. Therefore, the objective of the study was to develop a quantification model based on X-ray powder diffractometry (XRPD), followed by a multivariate partial least squares regression approach that enables the simultaneous determination of up to four solid state fractions: crystalline naproxen, γ-indomethacin, α-indomethacin as well as co-amorphous naproxen-indomethac

SUBMITTER: Beyer A 

PROVIDER: S-EPMC6332358 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature