Sim1000G: a user-friendly genetic variant simulator in R for unrelated individuals and family-based designs.

ABSTRACT:

Background

Simulation of genetic variants data is frequently required for the evaluation of statistical methods in the fields of human and animal genetics. Although a number of high-quality genetic simulators have been developed, many of them require advanced knowledge in population genetics or in computation to be used effectively. In addition, generating simulated data in the context of family-based studies demands sophisticated methods and advanced computer programming.

Results

To address these issues, we propose a new user-friendly and integrated R package, sim1000G, which simulates variants in genomic regions among unrelated individuals or among families. The only input needed is a raw phased Variant Call Format (VCF) file. Haplotypes are extracted to compute linkage di

SUBMITTER: Dimitromanolakis A 

PROVIDER: S-EPMC6332552 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature