Viral species richness and composition in young children with loose or watery stool in Ethiopia.

ABSTRACT:

Background

Stool consistency is an important diagnostic criterion in both research and clinical medicine and is often used to define diarrheal disease.

Methods

We examine the pediatric enteric virome across stool consistencies to evaluate differences in richness and community composition using fecal samples collected from children aged 0 to 5 years participating in a clinical trial in the Amhara region of Ethiopia. The consistency of each sample was graded according to the modified Bristol Stool Form Scale for children (mBSFS-C) before a portion of stool was preserved for viral metagenomic analysis. Stool samples were grouped into 29 pools according to stool consistency type. Differential abundance was determined using negative-binomial modeling.

Results

Of 446 census

SUBMITTER: Aiemjoy K 

PROVIDER: S-EPMC6332554 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature