An agent-based model of the Notch signaling pathway elucidates three levels of complexity in the determination of developmental patterning.

ABSTRACT:

Background

The Notch signaling pathway is involved in cell fate decision and developmental patterning in diverse organisms. A receptor molecule, Notch (N), and a ligand molecule (in this case Delta or Dl) are the central molecules in this pathway. In early Drosophila embryos, these molecules determine neural vs. skin fates in a reproducible rosette pattern.

Results

We have created an agent-based model (ABM) that simulates the molecular components for this signaling pathway as agents acting within a spatial representation of a cell. The model captures the changing levels of these components, their transition from one state to another, and their movement from the nucleus to the cell membrane and back to the nucleus again. The model introduces stochastic variation into the syst

SUBMITTER: Reynolds ER 

PROVIDER: S-EPMC6332573 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature