Prognostic signature associated with radioresistance in head and neck cancer via transcriptomic and bioinformatic analyses.

ABSTRACT:

Background

Radiotherapy is an indispensable treatment modality in head and neck cancer (HNC), while radioresistance is the major cause of treatment failure. The aim of this study is to identify a prognostic molecular signature associated with radio-resistance in HNC for further clinical applications.

Methods

Affymetrix cDNA microarrays were used to globally survey different transcriptomes between HNC cell lines and isogenic radioresistant sublines. The KEGG and Partek bioinformatic analytical methods were used to assess functional pathways associated with radioresistance. The SurvExpress web tool was applied to study the clinical association between gene expression profiles and patient survival using The Cancer Genome Atlas (TCGA)-head and neck squamous cell carcinoma (HNSCC

SUBMITTER: You GR 

PROVIDER: S-EPMC6332600 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature