Serious adverse events reported in placebo randomised controlled trials of oral naltrexone: a systematic review and meta-analysis.

ABSTRACT:

Background

Naltrexone is an opioid antagonist used in many different conditions, both licensed and unlicensed. It is used at widely varying doses from 3 to 250 mg. The aim of this review was to extensively evaluate the safety of oral naltrexone by examining the risk of serious adverse events and adverse events in randomised controlled trials of naltrexone compared to placebo.

Methods

A systematic search of the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, other databases and clinical trials registries was undertaken up to May 2018. Parallel placebo-controlled randomised controlled trials longer than 4 weeks published after 1 January 2001 of oral naltrexone at any dose were selected. Any condition or age group was included, excluding only studies in opioid

SUBMITTER: Bolton M 

PROVIDER: S-EPMC6332608 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature