Multi-omics integration reveals molecular networks and regulators of psoriasis.

ABSTRACT:

Background

Psoriasis is a complex multi-factorial disease, involving both genetic susceptibilities and environmental triggers. Genome-wide association studies (GWAS) and epigenome-wide association studies (EWAS) have been carried out to identify genetic and epigenetic variants that are associated with psoriasis. However, these loci cannot fully explain the disease pathogenesis.

Methods

To achieve a comprehensive mechanistic understanding of psoriasis, we conducted a systems biology study, integrating multi-omics datasets including GWAS, EWAS, tissue-specific transcriptome, expression quantitative trait loci (eQTLs), gene networks, and biological pathways to identify the key genes, processes, and networks that are genetically and epigenetically associated with psoriasis risk.

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC6332659 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature