Identifying primary site of lung-limited Cancer of unknown primary based on relative gene expression orderings.

ABSTRACT:

Background

Precise diagnosis of the tissue origin for metastatic cancer of unknown primary (CUP) is essential for deciding the treatment scheme to improve patients' prognoses, since the treatment for the metastases is the same as their primary counterparts. The purpose of this study is to identify a robust gene signature that can predict the origin for CUPs.

Methods

The within-sample relative gene expression orderings (REOs) of gene pairs within individual samples, which are insensitive to experimental batch effects and data normalizations, were exploited for identifying the prediction signature.

Results

Using gene expression profiles of the lung-limited metastatic colorectal cancer (LmCRC), we firstly showed that the within-sample REOs in lung metastases of colorecta

SUBMITTER: Li M 

PROVIDER: S-EPMC6332677 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature