Redox Dual-Responsive and O₂‑Evolving Theranostic Nanosystem for Highly Selective Chemotherapy against Hypoxic Tumors.

ABSTRACT: Activatable theranostic agents, which combine fluorescent reporters with masked chemotherapeutic agents that are activated by tumor-associated stimuli, would be attractive candidates to improve the tumor selectivity of chemotherapy. This work reports a ROS/GSH dual-activatable and O₂‑evolving theranostic nanosystem (RA-S-S-Cy@PLGA NPs) for highly selective therapy against hypoxic tumors and in situ fluorescence-tracking of cancer chemotherapy. Methods: In this system, the newly designed theranostic agent (RA-S-S-Cy) is composed of a disulfide bond as a cleavable linker, a near infrared (NIR) active fluorophore as a fluorescent tracker, and a natural cyclopeptide RA-V as the active anti-cancer agent. Upon reaction with the high level of intracellular glutathione (GS

SUBMITTER: Chen H 

PROVIDER: S-EPMC6332786 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature