MicroRNA expression profile of HCT-8 cells in the early phase of Cryptosporidium parvum infection.

ABSTRACT:

Background

Cryptosporidium parvum is an important zoonotic parasitic disease worldwide, but the molecular mechanisms of the host-parasite interaction are not fully understood. Noncoding microRNAs (miRNAs) are considered key regulators of parasitic diseases. Therefore, we used microarray, qPCR, and bioinformatic analyses to investigate the intestinal epithelial miRNA expression profile after Cryptosporidium parvum infection.

Results

Twenty miRNAs were differentially expressed after infection (four upregulated and 16 downregulated). Further analysis of the differentially expressed miRNAs revealed that many important cellular responses were triggered by Cryptosporidium parvum infection, including cell apoptosis and the inflammatory and immune responses.

Conclusions

This

SUBMITTER: Wang C 

PROVIDER: S-EPMC6332841 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature