Computational Studies Applied to Flavonoids against Alzheimer's and Parkinson's Diseases.

ABSTRACT: Neurodegenerative diseases, such as Parkinson's and Alzheimer's, are understood as occurring through genetic, cellular, and multifactor pathophysiological mechanisms. Several natural products such as flavonoids have been reported in the literature for having the capacity to cross the blood-brain barrier and slow the progression of such diseases. The present article reports on in silico enzymatic target studies and natural products as inhibitors for the treatment of Parkinson's and Alzheimer's diseases. In this study we evaluated 39 flavonoids using prediction of molecular properties and in silico docking studies, while comparing against 7 standard reference compounds: 4 for Parkinson's and 3 for Alzheimer's. Osiris analysis revealed that most of the flavonoids presented no to

SUBMITTER: Monteiro AFM 

PROVIDER: S-EPMC6332933 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature