Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment.

ABSTRACT: Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions. In recent years, large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientific details about tumor heterogeneity, with significant implications for the choice of specific molecular biomarkers and clinical decision making. Genomic heterogeneity significantly contributes to the generation of a diverse cell population during tumor development and progression, representing a determining factor for variation in tumor treatment response. It has been considered a prominent contributor to therapeutic failure, and increases the likelihood of resistance to future therapies in most common cancers. Th

SUBMITTER: Zhang J 

PROVIDER: S-EPMC6333046 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature