A functional assay to identify amyloidogenic light chains.

ABSTRACT:

Introduction

Multiple myeloma (MM) and light chain monoclonal gammopathy of undetermined significance (LCMGUS) are plasma cell disorders associated with the secretion of monoclonal free light-chain (LC) proteins. Due to the high concentrations of LC in circulation, both of these populations are at risk for developing LC-associated amyloidosis (AL) - a protein misfolding disease characterized by the deposition of LC protein fibrils in organs and tissues, leading to dysfunction and significant morbidity. At present, accurate identification of subjects at risk for developing amyloidosis is not possible, but with the advent of novel, amyloid-targeted therapies, identification of pre-symptomatic individuals is of clinical import.

Methods

To address this, a competition assay has b

SUBMITTER: Martin EB 

PROVIDER: S-EPMC6333307 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature