Genetic Analysis of PICK1 Gene in Alzheimer's Disease: A Study for Finding a New Gene Target.

ABSTRACT: Background: Alzheimer's disease (AD) is a neurodegenerative disease with no effective treatment. Researchers have focused on exploring biomarkers for its early diagnosis, especially on finding a new gene target. Recent studies have shown that protein interacting with C-kinase-1(PICK1) is related to AD through regulating hippocampal synaptic plasticity. PICK1 gene polymorphisms have been identified in psychological and other related disorders. Methods: This study included 133 sporadic AD patients and 173 healthy controls. All coding exons and intron-exon boundaries of the PICK1 gene were amplified by polymerase chain reaction (PCR), which were subsequently sequenced and analyzed. Results: This is the first genetic association study to investigate the association between PICK1 gene and AD ri

SUBMITTER: Xu L 

PROVIDER: S-EPMC6333664 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature