Genetic Diversity of <i>norA</i>, Coding for a Main Efflux Pump of <i>Staphylococcus aureus</i>.

ABSTRACT: NorA is the best studied efflux system of Staphylococcus aureus and therefore frequently used as a model for investigating efflux-mediated resistance in this pathogen. NorA activity is associated with resistance to fluoroquinolones, several antiseptics and disinfectants and several reports have pointed out the role of efflux systems, including NorA, as a first-line response to antimicrobials in S. aureus. Genetic diversity studies of the gene norA have described three alleles; norAI, norAII and norAIII. However, the epidemiology of these alleles and their impact on NorA activity remains unclear. Additionally, increasing studies do not account for norA variability when establishing relations between resistance phenotypes and norA prese

SUBMITTER: Costa SS 

PROVIDER: S-EPMC6333699 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature