PET imaging of [¹¹C]PBR28 in Parkinson's disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding.

ABSTRACT:

Purpose

To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson's disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD.

Methods

The radioligand [¹¹C]PBR28 was used for quantitative assessment of brain TSPO in 16 control subjects and 16 PD patients. To analyse the relationship between dopaminergic pathology and brain TSPO binding, PET studies of the dopamine transporter (DAT) were undertaken in PD patients using the DAT radioligand [¹⁸F]FE-PE2I. The total distribution volume of [¹¹C]PBR28 was quantified in nigrostriatal regions, limbic cortices and thalamus, and the binding potential of [¹⁸

SUBMITTER: Varnas K 

PROVIDER: S-EPMC6333720 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature