Effects of BDNF Val⁶⁶Met genotype and schizophrenia familial risk on a neural functional network for cognitive control in humans.

ABSTRACT: Cognitive control represents an essential neuropsychological characteristic that allows for the rapid adaption of a changing environment by constant re-allocation of cognitive resources. This finely tuned mechanism is impaired in psychiatric disorders such as schizophrenia and contributes to cognitive deficits. Neuroimaging has highlighted the contribution of the anterior cingulate cortex (ACC) and prefrontal regions (PFC) on cognitive control and demonstrated the impact of genetic variation, as well as genetic liability for schizophrenia. In this study, we aimed to examine the influence of the functional single-nucleotide polymorphism (SNP) rs6265 of a plasticity-related neurotrophic factor gene, BDNF (Val⁶⁶Met), on cognitive control. Strong evidence implicates BDNF Val^66<

SUBMITTER: Schweiger JI 

PROVIDER: S-EPMC6333795 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature