The Tri-phasic Role of Hydrogen Peroxide in Blood-Brain Barrier Endothelial cells.

ABSTRACT: Hydrogen peroxide (H₂O₂) plays an important role physiologically as the second messenger and pathologically as an inducer of oxidative stress in injury, ischemia and other conditions. However, it is unclear how H₂O₂ influences various cellular functions in health and disease differentially, particularly in the blood-brain barrier (BBB). We hypothesized that the change in cellular concentrations of H₂O₂ is a major contributor in regulation of angiogenesis, barrier integrity/permeability and cell death/apoptosis in BBB endothelial cells. Rat brain microvascular endothelial cells were exposed to various concentrations of H₂O₂ (1 nM to 25 mM). BBB tight junction protein (zonula ocludens-1; ZO-1) localizatio

SUBMITTER: Anasooya Shaji C 

PROVIDER: S-EPMC6333800 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature