Downregulated Caveolin-1 expression in circulating monocytes may contribute to the pathogenesis of psoriasis.

ABSTRACT: Caveolin-1 (CAV-1) is the principal component of caveolae that regulates a variety of signaling molecules and receptors. Our previous study revealed CAV-1 reduction in the epidermis of patients with psoriasis, which leads to enhanced Janus kinase/signal transducer and activator of transcription activation and cytokine production, suggesting that aberrant CAV-1 expression may contribute to psoriatic inflammation. This study aimed to investigate whether abnormal modulation of CAV-1 on immune cells is involved in the pathogenesis of psoriasis. We observed that CAV-1 level in psoriasis patients was apparently reduced in peripheral blood mononuclear cells (PBMCs) and it was prominent in CD14⁺ monocytes. CAV-1 silencing in monocytes represented elevated levels of interleukin (IL)-1β a

SUBMITTER: Takamura N 

PROVIDER: S-EPMC6333821 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature