Urinary tetrahydrocannabinol is associated with poorer working memory performance and alterations in associated brain activity.

ABSTRACT: Worldwide, cannabis is one of the most widely used psychoactive substances and cannabis use has been implicated in poorer performance in several cognitive domains, including working memory (WM). However, the neural mechanisms underlying these WM decrements are not well understood and the current study investigated the association of cannabis involvement with WM performance and associated neural activation in the Human Connectome Project (N = 1038). Multiple indicators of cannabis involvement were examined in relation to behavioral performance and brain activity in a visual N-back task using functional magnetic resonance imaging. A positive urine drug screen for tetrahydocannabinol (THC+ status), the principal psychoactive constituent in cannabis, was associated with worse WM performance an

SUBMITTER: Owens MM 

PROVIDER: S-EPMC6333822 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature