Longitudinal Connectomes as a Candidate Progression Marker for Prodromal Parkinson's Disease.

ABSTRACT: Parkinson's disease is the second most prevalent neurodegenerative disorder in the Western world. It is estimated that the neuronal loss related to Parkinson's disease precedes the clinical diagnosis by more than 10 years (prodromal phase) which leads to a subtle decline that translates into non-specific clinical signs and symptoms. By leveraging diffusion magnetic resonance imaging brain (MRI) data evaluated longitudinally, at least at two different time points, we have the opportunity of detecting and measuring brain changes early on in the neurodegenerative process, thereby allowing early detection and monitoring that can enable development and testing of disease modifying therapies. In this study, we were able to define a longitudinal degenerative Parkinson's disease progression patter

SUBMITTER: Pena-Nogales O 

PROVIDER: S-EPMC6333847 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature