Novel Pyoverdine Inhibitors Mitigate Pseudomonas aeruginosa Pathogenesis.

ABSTRACT: Pseudomonas aeruginosa is a clinically important pathogen that causes a variety of infections, including urinary, respiratory, and other soft-tissue infections, particularly in hospitalized patients with immune defects, cystic fibrosis, or significant burns. Antimicrobial resistance is a substantial problem in P. aeruginosa treatment due to the inherent insensitivity of the pathogen to a wide variety of antimicrobial drugs and its rapid acquisition of additional resistance mechanisms. One strategy to circumvent this problem is the use of anti-virulent compounds to disrupt pathogenesis without directly compromising bacterial growth. One of the principle regulatory mechanisms for P. aeruginosa's virulence is the iron-scavenging siderophore pyoverdine, as it governs in-host acquisition of iro

SUBMITTER: Kirienko DR 

PROVIDER: S-EPMC6333909 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature