Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa.

ABSTRACT:

Background

Pseudomonas aeruginosa often causes multidrug-resistant infections in immunocompromised patients, and polymyxins are often used as the last-line therapy. Alarmingly, resistance to polymyxins has been increasingly reported worldwide recently. To rescue this last-resort class of antibiotics, it is necessary to systematically understand how P. aeruginosa alters its metabolism in response to polymyxin treatment, thereby facilitating the development of effective therapies. To this end, a genome-scale metabolic model (GSMM) was used to analyze bacterial metabolic changes at the systems level.

Findings

A high-quality GSMM iPAO1 was constructed for P. aeruginosa PAO1 for antimicrobial pharmacological research. Model iPAO1 encompasses an additional periplasmic compartment

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC6333913 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature