Boundary behaviours of Leishmania mexicana: A hydrodynamic simulation study.

ABSTRACT: It is well established that the parasites of the genus Leishmania exhibit complex surface interactions with the sandfly vector midgut epithelium, but no prior study has considered the details of their hydrodynamics. Here, the boundary behaviours of motile Leishmania mexicana promastigotes are explored in a computational study using the boundary element method, with a model flagellar beating pattern that has been identified from digital videomicroscopy. In particular a simple flagellar kinematics is observed and quantified using image processing and mode identification techniques, suggesting a simple mechanical driver for the Leishmania beat. Phase plane analysis and long-time simulation of a range of Leishmania swimming scenarios demonstrate an absence of stable boundary motility for an id

SUBMITTER: Walker BJ 

PROVIDER: S-EPMC6333917 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature