Neurophysiologic measures of target engagement predict response to auditory-based cognitive training in treatment refractory schizophrenia.

ABSTRACT: Cognitive impairment is a core feature of schizophrenia and a strong predictor of psychosocial disability. Auditory-based targeted cognitive training (TCT) aims to enhance verbal learning and other domains of cognitive functioning through "bottom-up" tuning of the neural systems underlying early auditory information processing (EAIP). Although TCT has demonstrated efficacy at the group level, individual response to TCT varies considerably, with nearly half of patients showing little-to-no benefit. EEG measures of EAIP, mismatch negativity (MMN) and P3a, are sensitive to the neural systems engaged by TCT exercises and might therefore predict clinical outcomes after a full course of treatment. This study aimed to determine whether initial malleability of MMN and P3a to 1-h of auditory-based

SUBMITTER: Hochberger WC 

PROVIDER: S-EPMC6333927 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature