The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population.

ABSTRACT:

Background

Tumor necrosis factor-alpha (TNF-α) is an important cytokine in acute inflammatory response to infective factors. Based on investigation in different populations, it is thought that this response increases in patients with endometriosis due to the presence of cytokines such as TNF-α. This study aimed to examine the association of four TNF-α polymorphisms, namely -238G/A, -308G/A, -857C/T and -863C/A, with susceptibility to endometriosis in an Iranian population.

Materials and methods

We recruited 150 women with endometriosis and 150 women without endometriosis in this case-control study and collected 4 ml of blood from all subjects. After DNA extraction, the polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFL

SUBMITTER: Babaabasi B 

PROVIDER: S-EPMC6334017 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature