BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization.

ABSTRACT:

Objective

The aim of this study was to obtain estimates of the causal relationship between BMI and mortality.

Methods

Mendelian randomization (MR) with BMI-associated genotypic variation was used to test the causal effect of BMI on all-cause and cause-specific mortality in UK Biobank participants of White British ancestry.

Results

MR analyses supported a causal association between higher BMI and greater risk of all-cause mortality (hazard ratio [HR] per 1 kg/m² : 1.03; 95% CI: 0.99-1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01-1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00-1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03-1.48), stomach cancer (HR: 1.18; 95% CI: 0.8

SUBMITTER: Wade KH 

PROVIDER: S-EPMC6334168 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature