Common conditions associated with hereditary haemochromatosis genetic variants: cohort study in UK Biobank.

ABSTRACT:

Objective

To compare prevalent and incident morbidity and mortality between those with the HFE p.C282Y genetic variant (responsible for most hereditary haemochromatosis type 1) and those with no p.C282Y mutations, in a large UK community sample of European descent.

Design

Cohort study.

Setting

22 centres across England, Scotland, and Wales in UK Biobank (2006-10).

Participants

451 243 volunteers of European descent aged 40 to 70 years, with a mean follow-up of seven years (maximum 9.4 years) through hospital inpatient diagnoses and death certification.

Main outcome measure

Odds ratios and Cox hazard ratios of disease rates between participants with and without the haemochromatosis mutations, adjusted for age, genotyping array type, and genetic pri

SUBMITTER: Pilling LC 

PROVIDER: S-EPMC6334179 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature