Rapid Next-Generation Sequencing Method for Prediction of Prostate Cancer Risks.

ABSTRACT: Prostate cancer is the most commonly diagnosed male cancer and the second leading cause of cancer deaths among men in the United States, with approximately 220,000 new diagnoses and approximately 27,000 deaths each year. Men with clinical low-risk disease can receive active surveillance to safely preserve quality of life, provided that the risk of an undetected aggressive cancer can be managed. Thus, prediction of a tumor's metastatic potential, ideally using only a biopsy sample, is critical to choosing appropriate treatment. We previously proposed and verified a metastasis potential score (MPS) based on regions prone to copy number alterations in metastatic prostate cancer; MPS is highly predictive of metastatic potential in primary tumors. We developed a novel, targeted postligation amp

SUBMITTER: Fofanov VY 

PROVIDER: S-EPMC6334266 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature