Serum testosterone, sex hormone-binding globulin and sex-specific risk of incident type 2 diabetes in a retrospective primary care cohort.

ABSTRACT:

Objective

Previous studies suggest that androgens have a sexually dimorphic impact on metabolic dysfunction. However, the sex-specific link between circulating androgens and risk of type 2 diabetes mellitus (T2DM) has not been examined in a large scale, longitudinal cohort, a task we undertook in this study.

Design

A retrospective cohort study in a UK primary care database.

Patients

We included men and women with available serum testosterone and sex hormone-binding globulin (SHBG) results.

Measurements

We categorized serum concentrations according to clinically relevant cut-off points and calculated crude and adjusted T2DM Incidence Rate Ratios (IRRs and aIRRs).

Results

Serum testosterone concentrations were available in 70 541 men and 81 889 women; seru

SUBMITTER: O'Reilly MW 

PROVIDER: S-EPMC6334272 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature