Hepatic peroxisome proliferator-activated receptor alpha mediates the major metabolic effects of Wy-14643.

ABSTRACT:

Background and aim

Peroxisome proliferator-activated receptor alpha (PPARα) is a molecular target of various fibrate drugs clinically used to lower serum lipids. However, the tissue-specific functions of PPARα remain to be elucidated. This study aimed to explore the tissue-specific functions of PPARα in response to Wy-14643.

Methods

A hepatocyte-specific Ppara knockout mouse line was used to explore the impact of hepatic PPARα activity on the systemic response to treatment with the potent PPARα agonist Wy-14643.

Results

Wy-14643 mainly activated hepatic PPARα and regulated the expression of PPARα target genes in liver. Hepatic Ppara disruption abolished the triglyceride lowering effects of Wy-14643, prevented agonist-induced hypophagia, and ablated PPARα target gene r

SUBMITTER: Li G 

PROVIDER: S-EPMC6334298 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature