Genome-Based Approach Delivers Vaccine Candidates Against Pseudomonas aeruginosa.

ABSTRACT: High incidence, severity and increasing antibiotic resistance characterize Pseudomonas aeruginosa infections, highlighting the need for new therapeutic options. Vaccination strategies to prevent or limit P. aeruginosa infections represent a rational approach to positively impact the clinical outcome of risk patients; nevertheless this bacterium remains a challenging vaccine target. To identify novel vaccine candidates, we started from the genome sequence analysis of the P. aeruginosa reference strain PAO1 exploring the reverse vaccinology approach integrated with additional bioinformatic tools. The bioinformatic approaches resulted in the selection of 52 potential antigens. These vaccine candidates were conserved in P. aeruginosa genomes from different origin an

SUBMITTER: Bianconi I 

PROVIDER: S-EPMC6334337 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature