Investigation of Nonmotor Symptoms in First-Degree Relatives of Patients with Different Clinical Types of Parkinson's Disease.

ABSTRACT:

Background

Nonmotor symptoms (NMS) are prodromal characteristics of Parkinson's disease (PD). The first-degree relatives (FDR) of PD patients had a higher risk of PD and also had more NMS.

Objective

To delineate NMS in FDR of patients with different clinical types of PD.

Methods

A total of 98 PD probands were recruited; 256 siblings of them were enrolled in the FDR group. Various scales were used to assess NMS, including depression, anxiety, cognitive impairment, insomnia, constipation, excessive daytime sleepiness, rapid eye movement sleep behavior disorder (RBD), and restless legs syndrome (RLS). The incidences of NMS were further compared between the FDR groups of PD with different types.

Results

The FDR of early-onset PD (EOP) showed a higher incidence of m

SUBMITTER: Liu JB 

PROVIDER: S-EPMC6334354 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature