Genetic polymorphisms associated with nonalcoholic fatty liver disease in Uyghur population: a case-control study and meta-analysis.

ABSTRACT:

Background

Polymorphisms have been identified to predispose to NAFLD. Here, we accessed the seven polymorphisms of rs1260326, rs780094 in GCKR, rs2954021 near TRIB1, rs2228603 in NCAN, rs58542926 in TM6SF2, rs12137855 near LYPLAL1, and rs10883437 near CPN1 on NAFLD susceptibility in the Uygur population.

Material and methods

We collected 620 samples (317 NAFLD and 303 controls) for this case-control study. Meta-analysis was performed using Stata Software.

Results

Our data detected that the rs1260326 (T vs. C: OR = 1.27, 95% CI = 1.01-1.59) and rs780094 (T vs. C: OR = 1.30, 95% CI = 1.04-1.63) were significantly associated with the susceptibility to NAFLD in Uygur population. The rs1260326 and rs780094 T/T genotype are significantly associated with soda, egg, and soybe

SUBMITTER: Cai W 

PROVIDER: S-EPMC6334439 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature