Dominant role of microglial and macrophage innate immune responses in human ischemic infarcts.

ABSTRACT: Inflammatory mechanisms, involving granulocytes, T-cells, B-cells, macrophages and activated microglia, have been suggested to play a pathogenic role in experimental models of stroke and may be targets for therapeutic intervention. However, knowledge on the inflammatory response in human stroke lesions is limited. Here, we performed a quantitative study on the inflammatory reaction in human ischemic infarct lesions. We found increased numbers of T-lymphocytes, mainly CD8⁺ cells, but not of B-lymphocytes. Their number was very low in comparison to that seen in inflammatory diseases of the central nervous system and they did not show signs of activation. Polymorphonuclear leukocytes were present in meninges and less prominently in the perivascular space in early lesions, but their

SUBMITTER: Zrzavy T 

PROVIDER: S-EPMC6334527 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature