Abnormal calcium signalling and the caffeine-halothane contracture test.

ABSTRACT:

Background

The variable clinical presentation of malignant hyperthermia (MH), a disorder of calcium signalling, hinders its diagnosis and management. Diagnosis relies on the caffeine-halothane contracture test, measuring contraction forces upon exposure of muscle to caffeine or halothane (F_C and F_H, respectively). Patients with above-threshold F_C or F_H are diagnosed as MH susceptible. Many patients test positive to halothane only (termed 'HH'). Our objective was to determine the characteristics of these HH patients, including their clinical symptoms and features of cytosolic Ca²⁺ signalling related to excitation-contraction coupling in myotubes.

Methods

After institutional ethics committee approval, recruited patients un

SUBMITTER: Figueroa L 

PROVIDER: S-EPMC6334558 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature