An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice.

ABSTRACT: Cerebral ischemia activates an endogenous repair program that induces plastic changes in neurons. In this study, we investigated the effects of environmental enrichment on spatial learning and memory as well as on synaptic remodeling in a mouse model of chronic cerebral ischemia, produced by subjecting adult male C57BL/6 mice to permanent left middle cerebral artery occlusion. Three days postoperatively, mice were randomly assigned to the environmental enrichment and standard housing groups. Mice in the standard housing group were housed and fed a standard diet. Mice in the environmental enrichment group were housed in a cage with various toys and fed a standard diet. Then, 28 days postoperatively, spatial learning and memory were tested using the Morris water maze. The expression levels o

SUBMITTER: Wang CJ 

PROVIDER: S-EPMC6334594 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature