Progressive dissociation of cortical and subcortical network development in children with new-onset juvenile myoclonic epilepsy.

ABSTRACT:

Objective

Structural and functional magnetic resonance imaging (MRI) studies have consistently documented cortical and subcortical abnormalities in patients with juvenile myoclonic epilepsy (JME). However, little is known about how these structural abnormalities emerge from the time of epilepsy onset and how network interactions between and within cortical and subcortical regions may diverge in youth with JME compared to typically developing children.

Methods

We examined prospective covariations of volumetric differences derived from high-resolution structural MRI during the first 2 years of epilepsy diagnosis in a group of youth with JME (n = 21) compared to healthy controls (n = 22). We indexed developmental brain changes using graph theory by computing network metrics bas

SUBMITTER: Garcia-Ramos C 

PROVIDER: S-EPMC6334640 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature