Evidence for a Causal Role of the SH2B3-β₂M Axis in Blood Pressure Regulation.

ABSTRACT: Genetic variants at SH2B3 are associated with blood pressure and circulating β₂M (β-2 microglobulin), a well-characterized kidney filtration biomarker. We hypothesize that circulating β₂M is an independent risk predictor of hypertension and may causally contribute to its development. The study sample consisted of 7 065 Framingham Heart Study participants with measurements of plasma β₂M. Generalized estimating equations were used to test the association of β₂M with prevalent and new-onset hypertension. There were 2 145 (30%) cases of prevalent hypertension at baseline and 886 (21%) cases of incident hypertension during 6 years of follow-up. A 1-SD increase in baseline plasma β₂M was associated with a greater risk of prevalent (odds rati

SUBMITTER: Keefe JA 

PROVIDER: S-EPMC6334659 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature